![]() An active substance was isolated from the ethanol extract of G. thunbergii extract and investigated their chemical properties in this study. Therefore, we screened for Aβ42 aggregation inhibitors among components of a G. We screened for Aβ42 aggregation inhibitory activity using various plant extracts and compounds, and found high activity for a Geranium thunbergii extract (EC 50 = 18 μg/mL). Therefore, Aβ aggregation-inhibiting substances may contribute to the prevention and treatment of AD. These toxicity-induced neuronal damage and shedding processes advance AD progression. Amyloid β (Aβ) aggregates in the brains of patients with Alzheimer's disease (AD) and accumulates via oligomerization and subsequent fiber elongation processes.
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